Don Tillman, a socially challenged Professor of Genetics, is struggling to meet the right person. Tillman embarks on a mission to find that perfect person. Her organizes the Rosie Project; an elaborate, specific and well organized scientific based project to help him find his soul mate. But he soon learns that love and romance are not so easy predicted. Narrated by the awkward, yet endearing professor, The Rosie Project is an international sensation.